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ICHTHAMMOL the ammonium salt of dark sulfonated shale oil (DSSO) is used successfully as active pharmaceutical ingredient of natural origin for more than 100 years in treatment of skin disorders. Ichthammol is a product of natural origin obtained in the first step by dry distillation of sulfur-rich oil shale. It is used in medicine as a remedy for treating some skin diseases, such as acne, eczema and psoriasis.
Pharmacologically, DSSO have anti-inflammatory, bactericidal and fungicidal properties. It used in such preparations like:
| Specifications | Accepted limits | ||
|---|---|---|---|
| EP, BP grades | USP grade | ||
| 1 | Formation of a resinous precipitate | Corresponds | Corresponds |
| 2 | Reaction of ammonium salts | Corresponds | Corresponds |
| 3 | Identification of Sulphur | Corresponds | Corresponds |
| 4 | Acidity of Alkalinity | Corresponds | Corresponds |
| 5 | Sulphated Ash, max | 0.3% | 0.3% |
| 6 | Dry Matter | 50.0 – 56.0% | 50.0 – 56.0% |
| 7 | Total Sulphur, min | 14.0% | 10.0% |
| 8 | Sulphur in the form of Sulphate, max | 20% | Not determinated |
| 9 | Organically combined Sulphur, min | 10.5% | Not determinated |
| 10 | Ammonium Sulphate, max | Not determinated | 8% |
| 11 | Total ammonia | 4.5 – 7.0% | 2.5% Min. |
| 12 | Relative density | 1.040 – 1.085 | 1.040 – 1.085 |
| 13 | Consistency and Colour | Dense, blackish-brown liquid with specific smell | Dense, blackish-brown liquid with specific smell |
| 14 | Miscibility water and glycerol | Complete | Complete |
COA (Certificate of analysis).